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To further define the role of arachidonic acid (AA) metabolites in transfusion-induced immunosuppression (TII), the effects of pharmacological manipulation of AA metabolism were examined in a rodent model. If the prostaglandins of the E series are mediators of TII, as has been recently hypothesized, then inhibition of cyclooxygenase (indomethacin) should abrogate whereas inhibition of lipoxygenase (nordihydroguaiaretic acid [NDGA]), or thromboxane synthetase (4-63557A) could potentiate the transfusion effect. Lewis rats received donor-specific transfusions from Buffalo rats in conjunction with one of the above inhibitors. Two weeks later they received intraabdominal Buffalo heart allografts or were used for one-way mixed lymphocyte reactions. Cyclooxygenase inhibition partially abrogated TII with shortened cardiac allograft survival. Lipoxygenase inhibition augmented TII, with depression of MLR and prolongation of allograft survival. Thromboxane synthetase inhibition had no effect. These results indicate that AA metabolites play a role in TII, and that immunoregulation via pharmacological manipulation of AA metabolism is possible.
R V Perez, and
G F Babcock, and
J W Alexander
March 1988,
Transplantation,
R V Perez, and
G F Babcock, and
J W Alexander
December 1988,
Transplantation proceedings,
R V Perez, and
G F Babcock, and
J W Alexander
November 1988,
Clinical genetics,
R V Perez, and
G F Babcock, and
J W Alexander
March 1988,
Current eye research,
R V Perez, and
G F Babcock, and
J W Alexander
December 1987,
Biochemical and biophysical research communications,
R V Perez, and
G F Babcock, and
J W Alexander
January 1991,
Doklady Akademii nauk SSSR,
R V Perez, and
G F Babcock, and
J W Alexander
August 1983,
The Journal of pharmacology and experimental therapeutics,
R V Perez, and
G F Babcock, and
J W Alexander
January 1987,
The Journal of burn care & rehabilitation,
R V Perez, and
G F Babcock, and
J W Alexander
January 1991,
Advances in prostaglandin, thromboxane, and leukotriene research,
R V Perez, and
G F Babcock, and
J W Alexander
March 1988,
Archives of biochemistry and biophysics,
