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The chronotropic and inotropic effects of four atrial peptides (cardiodilatin 1-16, atrial natriuretic factor 8-33 and atriopeptin I and III) on the isolated systemic heart of Octopus vulgaris were studied. Using a preparation that produces a physiological stroke volume at physiological input pressures, it was found that ANF, atriopeptin I and atriopeptin III exerted both negative chronotropic and inotropic effects. In contrast, cardiodilatin produced a positive inotropic effect. A dose-response curve of ANF is reported, showing a threshold concentration of about 10(-12) M. The pharmacological and physiological implications of these results are discussed in relation to some characteristics of the cephalopod systemic heart.
C Agnisolo, and
L Cariello, and
A De Santis, and
A Miralto, and
B Tota
September 1984,
Japanese heart journal,
C Agnisolo, and
L Cariello, and
A De Santis, and
A Miralto, and
B Tota
April 2012,
Bulletin of experimental biology and medicine,
C Agnisolo, and
L Cariello, and
A De Santis, and
A Miralto, and
B Tota
June 2007,
The journal of physiological sciences : JPS,
C Agnisolo, and
L Cariello, and
A De Santis, and
A Miralto, and
B Tota
March 1983,
Japanese heart journal,
C Agnisolo, and
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B Tota
August 1992,
Arzneimittel-Forschung,
C Agnisolo, and
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A Miralto, and
B Tota
January 1997,
Fundamental & clinical pharmacology,
C Agnisolo, and
L Cariello, and
A De Santis, and
A Miralto, and
B Tota
April 1971,
The Journal of physiology,
C Agnisolo, and
L Cariello, and
A De Santis, and
A Miralto, and
B Tota
May 2013,
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences,
C Agnisolo, and
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A De Santis, and
A Miralto, and
B Tota
January 1998,
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia,
C Agnisolo, and
L Cariello, and
A De Santis, and
A Miralto, and
B Tota
January 1975,
The Tohoku journal of experimental medicine,
