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Biodegradable magnesium metal filaments placed inside biodegradable nerve conduits might provide the physical guidance support needed to improve the rate and extent of regeneration of peripheral nerves across injury gaps. In this study, we examined basic issues of magnesium metal resorption and biocompatibility by repairing sub-critical size gap injuries (6 mm) in one sciatic nerve of 24 adult male Lewis rats. Separated nerve stumps were connected with poly(caprolactone) nerve conduits, with and without magnesium filaments (0.25 mm diameter, 10 mm length), with two different conduit filler substances (saline and keratin hydrogel). At 6 weeks after implantation, magnesium degradation was examined by micro-computed tomography and histological analyses. Magnesium degradation was significantly greater when the conduits were filled with an acidic keratin hydrogel than with saline (p < 0.05). But magnesium filaments in some animals remained intact for 6 weeks. Using histological and immunocytochemical analyses, good biocompatibility of the magnesium implants was observed at 6 weeks, as shown by good development of regenerating nerve mini-fascicles and only mild inflammation in tissues even after complete degradation of the magnesium. Nerve regeneration was not interrupted by complete magnesium degradation. An initial functional evaluation, determination of size recovery of the gastrocnemius muscle, showed a slight improvement due to magnesium with the saline but not the keratin filler, compared with respective control conduits without magnesium. These results suggest that magnesium filament implants have the potential to improve repair of injured peripheral nerve defects in this rodent model.
J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
February 2007,
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
June 2016,
ACS biomaterials science & engineering,
J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
January 2003,
Acta physiologica Hungarica,
J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
January 1970,
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J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
May 1979,
Lancet (London, England),
J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
April 1979,
Lancet (London, England),
J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
January 1981,
International rehabilitation medicine,
J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
June 1946,
Surgery,
J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
June 2011,
The Ceylon medical journal,
J J Vennemeyer, and
T Hopkins, and
M Hershcovitch, and
K D Little, and
M C Hagen, and
D Minteer, and
D B Hom, and
K Marra, and
S K Pixley
January 2023,
Materials (Basel, Switzerland),
