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Comparative analysis of the pharmacokinetics and bioequivalence of a new dipeptide anxiolytic compound GB-115 in three drug forms for peroral administration, developed in the experimental technology department of the Institute of pharmacology RAMS, was carried out. Three drug forms of GB-115 and a micronized substance of this compound were different in composition and technology of production. As a result of the investigations of GB-115 pharmacokinetics, drug form No. 2 (with a relative bioequivalence of 192%) showed advantages in comparison to the micronized parent substance and two other drug forms (bioequivalence, 53 and 117%) and can be recommended for further pharmacological studies.
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
January 2015,
Eksperimental'naia i klinicheskaia farmakologiia,
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
June 2013,
Bulletin of experimental biology and medicine,
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
October 2012,
Bulletin of experimental biology and medicine,
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
May 2008,
Bulletin of experimental biology and medicine,
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
September 2007,
Bulletin of experimental biology and medicine,
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
June 2010,
Eksperimental'naia i klinicheskaia farmakologiia,
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
January 2011,
Vestnik Rossiiskoi akademii meditsinskikh nauk,
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
January 2011,
Eksperimental'naia i klinicheskaia farmakologiia,
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
March 1973,
Bollettino chimico farmaceutico,
E V Ivannikova, and
S S Boĭko, and
V P Zherdev, and
S Iu Raskin, and
E V Blynskaia, and
K G Turchinskaia, and
A A Illarionov
June 1980,
Vardfacket,
