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Pharmacokinetics and pharmacological activity of GB-115 dipeptide anxiolytic after oral administration in the form of crystalline and micronized substances was studied in albino male rats. In contrast to crystalline, the micronized substance exhibited better pharmacokinetic parameters and higher bioavailability. In the "elevated plus maze" test, GB-115 in micronized form at a dose 0.3 mg/kg demonstrated pronounced anxiolytic properties during prolonged period as compared to crystalline substance at the same dose. The obtained data allow the micronized substance of GB-115 to be recommended for inclusion in pharmaceutical composition of new dipeptide anxiolytic drug formulations.
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
January 2014,
Eksperimental'naia i klinicheskaia farmakologiia,
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
June 2013,
Bulletin of experimental biology and medicine,
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
September 2007,
Bulletin of experimental biology and medicine,
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
October 2012,
Bulletin of experimental biology and medicine,
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
January 2011,
Eksperimental'naia i klinicheskaia farmakologiia,
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
May 2008,
Bulletin of experimental biology and medicine,
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
June 2010,
Eksperimental'naia i klinicheskaia farmakologiia,
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
August 2012,
Bulletin of experimental biology and medicine,
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
January 2011,
Vestnik Rossiiskoi akademii meditsinskikh nauk,
L G Kolik, and
V P Zherdev, and
S S Boiko, and
M A Konstantinopol'skii, and
S Yu Raskin, and
T A Gudasheva, and
V A Mart'yanov, and
S B Seredenin
January 2013,
Bioorganicheskaia khimiia,
