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Liver plasma membranes of non-treated rats or rats treated with carbon tetrachloride were prepared. Liver plasma membranes obtained from non-treated rats were preincubated with cumene hydroperoxide, N-ethylmaleimide or hydrogen peroxide in the absence or presence of Fe2+. The effects of in-vivo or in-vitro treatment on hepatic alpha 1-adrenergic receptors were assessed in a [3H]prazosin binding assay. All treatments except preincubation with hydrogen peroxide alone caused a decrease in the number of alpha 1-adrenergic receptors without a change in the affinity of [3H]prazosin. The decrease in receptor number was accompanied by an increase in the level of lipid peroxidation in the plasma membranes. The results indicate that the hepatic alpha 1-adrenergic receptor is vulnerable to free radical stress.
F B Pruijn, and
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January 1982,
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F B Pruijn, and
J G van Gelderen, and
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September 1984,
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F B Pruijn, and
J G van Gelderen, and
A Bast
January 1985,
Proceedings of the National Academy of Sciences of the United States of America,
F B Pruijn, and
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December 1982,
European journal of pharmacology,
F B Pruijn, and
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Urology,
F B Pruijn, and
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F B Pruijn, and
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Biochemical pharmacology,
F B Pruijn, and
J G van Gelderen, and
A Bast
December 1992,
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F B Pruijn, and
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A Bast
September 1988,
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F B Pruijn, and
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A Bast
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