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Nucleoside analogs as non-substrate inhibitors of herpes simplex viruses thymidine kinase. 1989
F Focher, and
D Sandoli, and
C Hildebrand, and
S Sangalli, and
G Ciarrocchi, and
A Rebuzzini, and
G Pedrali-Noy, and
R Manservigi, and
G Wright, and
N Brown
Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Pavia, Italy.
We have examined the capacity of a series of 6-substituted pyrimidine and 2-substituted purine derivatives to inhibit mammalian thymidine kinase and the thymidine kinases encoded by type 1 and type 2 herpes simplex viruses. Several N2-substituted guanine and deoxy guanosine derivatives displayed selective inhibitory activity against the HSV-1 and HSV-2 thymidine kinases by competing with the phosphorylation of thymidine, suggesting a possible novel pharmacological approach to herpes viruses infections.
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