-transparent.png){kind=logo}
Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase. 2001
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
Department of Medicinal Chemistry, Roche Discovery Welwyn, Broadwater Road, Welwyn Garden City, AL7 3AY, Herts, UK. joseph.martin@roche.com
A series of carboxamide derivatives of 5'-amino-2',5'-dideoxy-5-ethyluridine has been prepared as inhibitors of HSV-TK (herpes simplex virus thymidine kinase). The most potent compounds were derived from xanthene, thioxanthene and dihydroanthracene carboxylic acids. The lead compounds show subnanomolar IC(50) values against HSV TKs.
Related Publications
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
September 1989,
Methods and findings in experimental and clinical pharmacology,
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
July 2002,
The Journal of antimicrobial chemotherapy,
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
April 1999,
Antiviral research,
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
February 1996,
Journal of virology,
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
December 1995,
Die Pharmazie,
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
April 2015,
Antiviral chemistry & chemotherapy,
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
November 2003,
Molecular microbiology,
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
September 2002,
Journal of medicinal chemistry,
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
March 1986,
Antiviral research,
J A Martin, and
R W Lambert, and
J H Merrett, and
K E Parkes, and
G J Thomas, and
S J Baker, and
D J Bushnell, and
J E Cansfield, and
S J Dunsdon, and
A C Freeman, and
R A Hopkins, and
I R Johns, and
E Keech, and
H Simmonite, and
A Walmsley, and
P Wong Kai-In, and
M Holland
December 2007,
The Journal of antimicrobial chemotherapy,
