Biomaterial Database

The effect of a dentifrice containing soluble pyrophosphate and a copolymer on calculus deposit: a six-month clinical study. 1989

T Triratana, and V Kerdvongbundit, and N Chutapimol, and S Thepbanterng

A six-month, double blind, cross over clinical study was conducted to compare the effect of a commercially available anticalculus dentifrice and a placebo dentifrice on supragingival calculus deposits. Fifty adult subjects who entered the study were given an oral prophylaxis and were assigned to use either pyrophosphate/copolymer toothpaste or a placebo toothpaste for a period of three months. They were then scored for calculus deposits using the Volpe-Manhold method, received a second oral prophylaxis and used the alternate dentifrice for a second three month period of time. The subjects were again scored for calculus deposits and the study was completed. The results indicated that pyrophosphate/copolymer toothpaste reduced supragingival calculus formation by 37.07%, as compared to the placebo dentifrice. This reduction was significant at the 99% level of confidence.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011756	Diphosphates	Inorganic salts of phosphoric acid that contain two phosphate groups.	Diphosphate,Pyrophosphate Analog,Pyrophosphates,Pyrophosphate Analogs,Analog, Pyrophosphate
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D003728	Dental Calculus	Abnormal concretion or calcified deposit that forms around the teeth or dental prostheses.	Tartar,Calculus, Dental
D003802	Dentifrices	Any preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medicaments and caries preventives.	Polishes, Dental,Dental Polishes,Dentifrice
D004311	Double-Blind Method	A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.	Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults