-transparent.png){kind=logo}
In rat prefrontal cortical slices, the excitatory amino acids N-methyl-D-aspartate (NMDA), ibotenate, L-aspartate, quisqualate, kainate and L-glutamate inhibit carbachol-induced phosphoinositide hydrolysis as measured by the accumulation of [3H]inositol-1-phosphate ([3H]IP1). NMDA dose-dependently inhibited the carbachol response (IC50 = 14.4 microM), and this inhibition was blocked by the NMDA receptor antagonist D,L-aminophosphonovaleric acid. Lowering medium Na+ concentration to 10 mM or exposing slices to pertussis toxin alleviated the inhibitory effect of NMDA on carbachol-induced [3H]IP1 formation. Serotonin-induced stimulation of [3H]IP1 was also inhibited by NMDA; in contrast, stimulation by norepinephrine, epinephrine or dopamine was unaffected. The results suggest that excitatory amino acids, besides their traditional role as stimulatory substances, can also act to inhibit the production of 2nd messengers activated by certain neurotransmitters in the brain.
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
December 1989,
Journal of neurochemistry,
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
May 1992,
Brain research,
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
February 1992,
Brain research,
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
September 1988,
Journal of neurochemistry,
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
January 1989,
Neurochemistry international,
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
July 1989,
Journal of neurochemistry,
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
September 1992,
Journal of neurochemistry,
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
November 1988,
Biochemical pharmacology,
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
October 1993,
Glia,
E P Noble, and
E Sincini, and
D Bergmann, and
G ten Bruggencate
February 1989,
Biochemical pharmacology,
