Spatial learning potentiates the stimulation of phosphoinositide hydrolysis by excitatory amino acids in rat hippocampal slices. 1988

F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
Institute of Pharmacology, University of Catania School of Medicine, Italy.

Stimulation of phosphoinositide (PI) hydrolysis by excitatory amino acids (glutamate and ibotenate) or norepinephrine was potentiated in hippocampal slices from rats trained in an eight-arm radial maze, used as a test of spatial learning. No difference in basal or carbamylcholine-stimulated PI hydrolysis was found between control and trained animals. An increased PI response to excitatory amino acids and norepinephrine was not found in hippocampal slices prepared from animals trained in a shock conditioning avoidance test. These results suggest a possible involvement of specific glutamate receptors coupled with PI hydrolysis in the synaptic mechanisms underlying formation and/or storage of spatial memory.

UI MeSH Term Description Entries
D007051 Ibotenic Acid A neurotoxic isoxazole (similar to KAINIC ACID and MUSCIMOL) found in AMANITA mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist. Acid, Ibotenic
D007295 Inositol Phosphates Phosphoric acid esters of inositol. They include mono- and polyphosphoric acid esters, with the exception of inositol hexaphosphate which is PHYTIC ACID. Inositol Phosphate,Phosphate, Inositol,Phosphates, Inositol
D007858 Learning Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge. Phenomenography
D008297 Male Males
D010080 Oxazoles Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions. Oxazole,1,3-Oxazolium-5-Oxides,Munchnones,1,3 Oxazolium 5 Oxides
D010716 Phosphatidylinositols Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids. Inositide Phospholipid,Inositol Phosphoglyceride,Inositol Phosphoglycerides,Inositol Phospholipid,Phosphoinositide,Phosphoinositides,PtdIns,Inositide Phospholipids,Inositol Phospholipids,Phosphatidyl Inositol,Phosphatidylinositol,Inositol, Phosphatidyl,Phosphoglyceride, Inositol,Phosphoglycerides, Inositol,Phospholipid, Inositide,Phospholipid, Inositol,Phospholipids, Inositide,Phospholipids, Inositol
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D005971 Glutamates Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure. Glutamic Acid Derivatives,Glutamic Acids,Glutaminic Acids
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D006868 Hydrolysis The process of cleaving a chemical compound by the addition of a molecule of water.

Related Publications

F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
May 1992, Brain research,
F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
May 1989, Zhongguo yao li xue bao = Acta pharmacologica Sinica,
F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
January 1989, Life sciences,
F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
February 1993, Neurochemical research,
F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
September 1989, Biochemical pharmacology,
F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
July 1990, Neurochemical research,
F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
September 1992, Journal of neurochemistry,
F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
September 1989, Journal of neurochemistry,
F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
January 1992, Neurotoxicology,
F Nicoletti, and C Valerio, and C Pellegrino, and F Drago, and U Scapagnini, and P L Canonico
February 1989, Biochemical pharmacology,
Copied contents to your clipboard!