Effects of 1,2,3,4-tetrahydroisoquinoline derivatives on dopaminergic spontaneous discharge in substantia nigra neurons in rats. 2015

Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
Department of Pharmacology, School of Pharmaceutical Sciences, Ohu University, Koriyama, Japan.

1,2,3,4-Tetrahydroisoquinoline (TIQ) and its derivatives, 1-methyl-TIQ (1-MeTIQ) and 1-benzyl-TIQ (1-BnTIQ), are endogenously present in the human brain. In this study, we compared the effects of TIQ derivatives on spontaneous nigral dopaminergic discharge in rats treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In the low-to-middle dose range (0.01-1 mg/kg), intravenous administration of MPTP induced a transient and potent increase in the firing rate. TIQ (0.01-30 mg/kg) had no effects, and 1-MeTIQ and 1-BnTIQ (0.01-10 mg/kg) produced a weaker increase in the firing frequency immediately after intravenous administration. Pretreatment with 1-MeTIQ (80 mg/kg, i.p.) significantly inhibited the decrease in dopaminergic spontaneous firing induced by a high dose of MPTP. The nigral induction of thiobarbituric acid-reactive substances (TBARS) by MPTP was also significantly suppressed by pretreatment with 1-MeTIQ. These results suggest that the neurotoxicity induced by TIQ derivatives is relatively weak compared to that induced by MPTP. The neuroprotective effect of 1-MeTIQ from MPTP-induced toxicity may be partially due to a decrease in free radicals, as suggested by a decrease in TBARS. This action presumably prevents cell membrane degeneration.

UI MeSH Term Description Entries
D008297 Male Males
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D009498 Neurotoxins Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept. Alpha-Neurotoxin,Excitatory Neurotoxin,Excitotoxins,Myotoxin,Myotoxins,Neurotoxin,Alpha-Neurotoxins,Excitatory Neurotoxins,Excitotoxin,Alpha Neurotoxin,Alpha Neurotoxins,Neurotoxin, Excitatory,Neurotoxins, Excitatory
D004298 Dopamine One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action. Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013378 Substantia Nigra The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis. Nigra, Substantia,Nigras, Substantia,Substantia Nigras
D015259 Dopamine Agents Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. Dopamine Drugs,Dopamine Effect,Dopamine Effects,Dopaminergic Agents,Dopaminergic Drugs,Dopaminergic Effect,Dopaminergic Effects,Agents, Dopamine,Agents, Dopaminergic,Drugs, Dopamine,Drugs, Dopaminergic,Effect, Dopamine,Effect, Dopaminergic,Effects, Dopamine,Effects, Dopaminergic
D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease. MPTP,N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D017392 Thiobarbituric Acid Reactive Substances Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct. TBARs

Related Publications

Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
March 2016, Brain research bulletin,
Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
January 1988, Zhen ci yan jiu = Acupuncture research,
Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
January 2004, Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban,
Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
May 1985, Life sciences,
Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
September 2009, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
January 2007, Progress in brain research,
Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
March 2001, Journal of neurophysiology,
Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
February 1994, Brain research,
Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
January 2007, Brain research,
Hikari Chiba, and Haruka Sato, and Kenji Abe, and Toshiaki Saito, and Yoshie Horiguchi, and Hiroshi Nojima, and Kyoji Taguchi
January 2009, Journal of neural transmission. Supplementum,
Copied contents to your clipboard!