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The effects of omeprazole (an H+, K+ -ATPase inhibitor) on thyroid parameters in rats have been examined. SK&F Wistar rats were dosed orally with omeprazole (up to 500 mg kg-1) or vehicle. Treatment for 7 or 14 days resulted in generally decreased plasma T3 concentrations in males (with little change or slight increases in females) and increased serum TSH concentrations (22%-68% increases). No changes were detected in thyroid 125I uptake or organification. Liver 5'-deiodinase activity was decreased in male rats after 7 days treatment. Thyroxine clearance was not altered after a single dose of omeprazole. In-vitro studies showed omeprazole to be only a weak inhibitor of TSH-stimulated 125I organification in cultured porcine thyrocytes. It is concluded that omeprazole has weak effects on the pituitary-thyroid-liver axis, its main action being to inhibit the peripheral deiodination of thyroid hormones.
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
October 1968,
Naika hokan. Japanese archives of internal medicine,
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
January 1987,
European journal of clinical pharmacology,
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
November 1983,
Archives of toxicology,
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
January 1952,
Archiv fur Dermatologie und Syphilis,
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
May 1986,
Clinical and experimental pharmacology & physiology,
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
October 1981,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
December 1955,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
January 1965,
Rivista di medicina aeronautica e spaziale,
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
January 1976,
Die Nahrung,
C K Atterwill, and
C G Brown, and
K L Fowler, and
C A Jones
August 1979,
The Indian journal of medical research,
