Effects of hemidecortication on the regulation of rat thyroid function. 1981

K O Nonaka, and N Iazigi, and R P Gonçalves, and J V Pereira-Leite, and J Antunes-Rodrigues

1. Thyroid function in hemidecorticate and control rats was studied by the measurement of oxygen consumption (under basal conditions and after cold exposure) and radioiodine (131 I) uptake by the thyroid after a low-iodine diet for 30 days. 2. The oxygen uptake of male and female hemidecorticate rats under basal conditions (29 degrees C) did not differ significantly from that of the controls. The values observed for both experimental groups were relatively constant, ranging from 40 to 75 kcal h-1 m-2 for 2 to 50-day-old animals. 3. When hemidecorticate and control rats, age 60-65 days, were exposed to 7-8 degrees C for 5-6 h, the oxygen consumption of the hemidecorticate rats increased (83-84 kcal h-1 m-2) but to a lower extent than that of the controls (105-106 kcal h-1 m-2). 4. The rate of radioiodine (131 I) uptake by the thyroid gland of hemidecorticate rats was also lower than that of controls when the animals were maintained on a low-iodine diet. 5. These results show that, under basal conditions, the hypothalamic-pituitary-thyroid axis of hemidecorticate rats does not differ from that of control rats. However, when exposed to cold the hemidecorticate animals were not able to increase their oxygen consumption to the extent achieved by the control groups.

UI MeSH Term Description Entries
D007457 Iodine Radioisotopes Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes. Radioisotopes, Iodine
D008297 Male Males
D009929 Organ Size The measurement of an organ in volume, mass, or heaviness. Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D010101 Oxygen Consumption The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346) Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D002541 Cerebral Decortication Partial or total removal, ablation, or destruction of the cerebral cortex; may be chemical. It is not used with animals that do not possess a cortex, i.e., it is used only with mammals. Decortication, Cerebral Cortex,Cerebral Cortex Decortication,Cerebral Cortex Decortications,Cerebral Decortications,Cortex Decortication, Cerebral,Cortex Decortications, Cerebral,Decortication, Cerebral,Decortications, Cerebral,Decortications, Cerebral Cortex
D003080 Cold Temperature An absence of warmth or heat or a temperature notably below an accustomed norm. Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D004032 Diet Regular course of eating and drinking adopted by a person or animal. Diets
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013960 Thyroid Function Tests Blood tests used to evaluate the functioning of the thyroid gland. Jostel's TSH Index,Jostel's Thyrotropin Index,Protein-Bound Iodine Test,SPINA-GD,SPINA-GT,Secretory Capacity of the Thyroid Gland,Sum Activity of Peripheral Deiodinases,Thyrotroph Thyroid Hormone Sensitivity Index,Thyroid Gland Function Tests,Function Test, Thyroid,Iodine Test, Protein-Bound,Jostel TSH Index,Jostel Thyrotropin Index,Jostel's TSH Indices,Jostels TSH Index,Jostels Thyrotropin Index,Protein Bound Iodine Test,Protein-Bound Iodine Tests,TSH Index, Jostel's,Test, Protein-Bound Iodine,Test, Thyroid Function,Thyroid Function Test,Thyrotropin Index, Jostel's

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