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Employing 16 polymorphic DNA markers as well as the chromosome 19 centromere heteromorphism, we have performed a genetic linkage study in 26 families with myotonic dystrophy. Fourteen of these markers had been assigned previously to one of five different intervals of the 19cen-19q13.2 segment by using somatic cell hybrids. For the long arm of chromosome 19, a genetic map that encompasses 9 polymorphic markers and the DM gene has been constructed. Our studies indicate that the DM and CKMM genes map distal to the ApoC2-ApoE gene cluster and to the anonymous polymorphic markers D19S15 and D19S16, but proximal to the D19S22 marker. The orientation of DM and CKMM remains to be determined.
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
November 1986,
Neurology,
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
August 1992,
Genomics,
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
February 1990,
Neurology,
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
November 1986,
Human genetics,
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
January 1989,
Genomics,
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
February 1989,
Genomics,
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
May 1989,
Human genetics,
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
January 1990,
Genomics,
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
July 1986,
Nucleic acids research,
H G Brunner, and
H Smeets, and
H M Lambermon, and
M Coerwinkel-Driessen, and
B A van Oost, and
B Wieringa, and
H H Ropers
August 1983,
Journal of medical genetics,
