Fish is known to-be a significant source of iodine and selenium for human beings. The aim of the present work was evaluation of iodine and selenium consumption levels with fish by residents of Moscow Region and Moscow. 400 Residents of Moscow and Moscow Region (100 children of 2-6 years age, 100 adults of 20-35 years age, 100 students of 18-22 years age and 100 elderly persons of 50-75 years age were inspected using values of ioduria and Se status determination. I concentration was determined by voltamperometric method, Se - via semiquantitative peroxide test. The values of ioduria for the inhabitants corresponded to moderate (Moscow Region, ioduria median 52,5 µg/l) and light (Moscow, ioduria mediane 67 µg/l) I deficiency with marginal Se deficiency in both cases (79-90% of persons had a negative peroxide test parameters, corresponding to serum Se level >90 µg/l). Though main fish species used by the population (humpback, trout, steelhead) contain relatively high levels of Se (505±46, 376±32, 413±22 µg/kg) and I (187±66, 290±102, 330±116 µg/kg), they are not able to maintain high I and Se status of the inhabitants due to low consumption level. I consumption with fish, being used once per week, reached 21 µg, Se - 35 µg per week. Up to 40% of students and 28% of elderly do not eat fish at all. Children of 2-6 years old residing in Moscow Region compose a specialgroup of ecological risk of I deficiencypossessing significant I deficiency 3 times more frequently than children from Moscow.