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Isosorbide mononitrate in a dose of 20 mg t.i.d. was used in 25 patients admitted few hours after acute myocardial infarction. The following parameters were analysed: systolic and diastolic blood pressure, heart rate, clinical features, and laboratory data. Heart rate and diastolic blood pressure remained unchanged, however systolic blood pressure was slightly reduced (p less than 0.01). There was a reduction in the angina episodes post-AMI. None of the patients included in the study had clinical deterioration or showed infarction extension. There were no changes in laboratory data. After the interruption of the drug, one patient died on the 6th day with acute mitral insufficiency. In conclusion, isosorbide mononitrate can be safely used during an uncomplicated acute myocardial infarction, without the risk of haemodynamic deterioration, and helps to prevent post-infarction angina.
L S Piegas, and
S Timerman, and
A Timerman, and
C Gun, and
R F Ramos, and
E R Romano, and
H M De Magalhães, and
J E Sousa
June 1990,
The American journal of cardiology,
L S Piegas, and
S Timerman, and
A Timerman, and
C Gun, and
R F Ramos, and
E R Romano, and
H M De Magalhães, and
J E Sousa
July 1990,
European heart journal,
L S Piegas, and
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C Gun, and
R F Ramos, and
E R Romano, and
H M De Magalhães, and
J E Sousa
March 1993,
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology,
L S Piegas, and
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A Timerman, and
C Gun, and
R F Ramos, and
E R Romano, and
H M De Magalhães, and
J E Sousa
January 1986,
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L S Piegas, and
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A Timerman, and
C Gun, and
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E R Romano, and
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J E Sousa
January 1987,
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L S Piegas, and
S Timerman, and
A Timerman, and
C Gun, and
R F Ramos, and
E R Romano, and
H M De Magalhães, and
J E Sousa
January 1987,
Cardiology,
L S Piegas, and
S Timerman, and
A Timerman, and
C Gun, and
R F Ramos, and
E R Romano, and
H M De Magalhães, and
J E Sousa
October 1991,
Kardiologiia,
L S Piegas, and
S Timerman, and
A Timerman, and
C Gun, and
R F Ramos, and
E R Romano, and
H M De Magalhães, and
J E Sousa
June 1990,
The American journal of cardiology,
L S Piegas, and
S Timerman, and
A Timerman, and
C Gun, and
R F Ramos, and
E R Romano, and
H M De Magalhães, and
J E Sousa
February 1990,
European heart journal,
L S Piegas, and
S Timerman, and
A Timerman, and
C Gun, and
R F Ramos, and
E R Romano, and
H M De Magalhães, and
J E Sousa
May 1984,
British journal of clinical pharmacology,
