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The present study was designed to investigate the possible deficits in the place learning on the 8-arm radial maze in aged rats. In this task, reward was given in the 4 predetermined arms. Aged rats (27 months old, N = 7) acquired this task more slowly than young rats (12 months old, N = 11), and didn't reach to the performance level of the young rats within 80 training trials. Analysis of error choices revealed that the aged animals first entered in the unbaited arms more often than the young rats, whereas there was no difference in the number of re-entered choices to the baited and unbaited arms between the aged and young animals. Therefore, it was concluded that learning deficits in aged rats were attributed to deficits in the reference memory but not in the working memory.
S Furukawa, and
T Iwasaki
October 2000,
Pharmacological research,
S Furukawa, and
T Iwasaki
August 2003,
Pharmacology, biochemistry, and behavior,
S Furukawa, and
T Iwasaki
November 1997,
Brain research,
S Furukawa, and
T Iwasaki
February 2006,
Learning & behavior,
S Furukawa, and
T Iwasaki
January 1982,
Psychopharmacology,
S Furukawa, and
T Iwasaki
November 1994,
Behavioral and neural biology,
S Furukawa, and
T Iwasaki
December 2004,
Pharmacology, biochemistry, and behavior,
S Furukawa, and
T Iwasaki
January 1988,
Neurotoxicology and teratology,
S Furukawa, and
T Iwasaki
December 1998,
Brain research,
S Furukawa, and
T Iwasaki
April 2000,
Brain research,
