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Studies were performed to determine whether [18F]6-fluorometaraminol (18F-FMR), a new neuronal heart radiopharmaceutical, is metabolized in vivo and if the metabolites are taken up in heart. Rat, dog, baboon and guinea pig were injected with 18F-FMR and tissue samples were analyzed for metabolites by HPLC. Liver contained the most metabolites of the tissues studied with 25-90% of the radioactivity present as metabolites at 1 h in all the species studied. While metabolites of 18F-FMR are found in blood, no significant accumulation of these metabolites is found in heart (less than or equal to 0.3%) 1 h after i.v. administration in any species except rat. These studies suggest that 18F-FMR is a suitable agent for quantitative imaging of the heart by positron emission tomography.
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
January 1997,
Clinical and experimental hypertension (New York, N.Y. : 1993),
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
February 1988,
Journal of medicinal chemistry,
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
March 2001,
Bioorganic & medicinal chemistry,
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
January 1978,
Arzneimittel-Forschung,
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
June 1989,
Xenobiotica; the fate of foreign compounds in biological systems,
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
April 1983,
Steroids,
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
July 1972,
Toxicology and applied pharmacology,
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
January 1985,
Naunyn-Schmiedeberg's archives of pharmacology,
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
September 2011,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
K C Rosenspire, and
D L Gildersleeve, and
C C Massin, and
S G Mislankar, and
D M Wieland
January 1991,
Anesteziologiia i reanimatologiia,
