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Carboxymethyl- and carboxy-derivatives of 7H- and 5H-1,2,4-triazolo [3,4-b][1,3,4] thiadiazine: synthesis and biological evaluation. 1989
G Mazzone, and
F Bonina, and
R Pignatello, and
A M Panico, and
A Caruso, and
M G Leone, and
M Amico-Roxas, and
G Blandino
Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania.
Some carboxymethyl- and carboxy-derivatives of 7H- and 5H-1,2,4-triazolo [3,4-b][1,3,4] thiadiazine were prepared. Their structure are discussed on the basis of IR, NMR and mass spectra. The synthesized compounds were subjected to a preliminary pharmacological screening for antiinflammatory-analgesic activity and to microbiological test on various species of mycetes and bacteria.
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