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The influence of buspirone upon plasma catecholamine levels, heart rate, and mean arterial blood pressure was studied in stressed and nonstressed rats. Measures were obtained directly via indwelling aortic catheters. Drug or vehicle were given acutely (10 mg/kg, IP) or twice a day for 10 days (10 mg and 20 mg/kg, SC). In nonstressed rats, a single dose of buspirone increased markedly plasma norepinephrine and epinephrine levels and decreased significantly heart rate with no effect on blood pressure. During stress, stress-induced increases in catecholamine levels were further elevated by the drug, whereas stress-induced increases of heart rate and mean arterial blood pressure were reduced. In chronically-pretreated rats, the effects of buspirone were similar to those observed after an acute injection. These effects of buspirone on plasma catecholamines are very different from those seen with other anxiolytics, whereas effects on heart rate and blood pressure are more similar.
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
June 1987,
Life sciences,
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
February 1991,
Pharmacology, biochemistry, and behavior,
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
January 1992,
Neuropharmacology,
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
January 1985,
The American journal of physiology,
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
May 1988,
Regulatory peptides,
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
October 1977,
Annals of the New York Academy of Sciences,
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
January 1983,
Clinical and experimental pharmacology & physiology,
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
December 1988,
International journal of oral and maxillofacial surgery,
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
March 1981,
Obstetrics and gynecology,
J Taylor, and
N Harris, and
M Krieman, and
W H Vogel
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Journal of cardiovascular pharmacology,
