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The effect of ethanol on the cardiovascular system (ECG, heart rate, blood pressure) was studied in anesthetized, nonstressed or stressed rats. In anesthetized rats, ethanol showed no effect on heart rate or ECG. In nonstressed rats, ethanol sedated the animals but increased heart rate significantly. This ethanol induced tachycardia seemed the result of a direct stimulation of the sympathetic nerves to the heart. Blood pressure was not significantly affected by ethanol in these nonstressed rats. In stressed rats, marked behavioral excitation and significant increases in heart rate and blood pressure were noted. Ethanol pretreatment calmed the animals considerably during restraint. Ethanol did reduce slightly the stress-induced tachycardia but markedly reduced or antagonized stress-induced blood pressure increases. No major changes in the ECG were noted during these studies with the exception of a few individual animals which showed pathologic ECG responses to ethanol. These data show that ethanol affects cardiovascular functions differently in anesthetized, nonstressed or stressed rats, and that ethanol can significantly reduce or antagonize stress-induced behavioral excitation, tachycardia and hypertension.
M G Sparrow, and
H Roggendorf, and
W H Vogel
October 1989,
Pharmacology, biochemistry, and behavior,
M G Sparrow, and
H Roggendorf, and
W H Vogel
July 1988,
Pharmacology, biochemistry, and behavior,
M G Sparrow, and
H Roggendorf, and
W H Vogel
March 1981,
Obstetrics and gynecology,
M G Sparrow, and
H Roggendorf, and
W H Vogel
January 1992,
Neuropharmacology,
M G Sparrow, and
H Roggendorf, and
W H Vogel
September 1986,
Research communications in chemical pathology and pharmacology,
M G Sparrow, and
H Roggendorf, and
W H Vogel
August 1997,
European journal of pharmacology,
M G Sparrow, and
H Roggendorf, and
W H Vogel
October 1977,
Annals of the New York Academy of Sciences,
M G Sparrow, and
H Roggendorf, and
W H Vogel
June 1989,
Australian veterinary journal,
M G Sparrow, and
H Roggendorf, and
W H Vogel
January 1999,
Clinical hemorheology and microcirculation,
M G Sparrow, and
H Roggendorf, and
W H Vogel
October 1998,
Yao xue xue bao = Acta pharmaceutica Sinica,
