Renal excretion of purine bases--effects of probenecid, benzbromarone and pyrazinamide. 1989

T Hada, and T Yamamoto, and Y Moriwaki, and S Takahashi, and K Higashino
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008297 Male Males
D008657 Metabolic Clearance Rate Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site. Total Body Clearance Rate,Clearance Rate, Metabolic,Clearance Rates, Metabolic,Metabolic Clearance Rates,Rate, Metabolic Clearance,Rates, Metabolic Clearance
D011339 Probenecid The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. Benecid,Benemid,Benuryl,Pro-Cid,Probecid,Probenecid Weimer
D011687 Purines A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
D011718 Pyrazinamide A pyrazine that is used therapeutically as an antitubercular agent. Tisamid
D006074 Gout Suppressants Agents that increase uric acid excretion by the kidney (URICOSURIC AGENTS), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout. Antigout Agents,Antihyperuricemic,Antihyperuricemics,Agents, Antigout,Suppressants, Gout
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D001553 Benzbromarone Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout. Acifugan,Benzbromaron,Benzbromaron AL,Benzbromaron-Ratiopharm,Besuric,Desuric,Narcaricin,Urinorm,AL, Benzbromaron,Benzbromaron Ratiopharm

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