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A case of carcinoma of the tongue treated with neoadjuvant chemotherapy has been reported. The patient was a 61-year-old man complaining of tumor and contact pain at the left margin of the tongue. The tumor was oval and elastic soft with pedicle, measuring 26 X 16 X 8 mm in size. The tumor was histopathologically diagnosed as a highly differentiated squamous cell carcinoma. The patient was treated with CDDP (75 mg/body) and PEP (5 mg/body) for 5 days. After two trials with about a 3-week interval, treatment result showed partial response. This result demonstrated that combination chemotherapy of CDDP and PEP is an effective regimen for remission neoadjuvant chemotherapy in patients with squamous cell carcinoma.
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