Biomaterial Database

[Recent Advances in Vaccines and Drugs Against the Ebola Virus]. 2015

Xiang Zhu, and Chenguang Yao, and Yanhong Wei, and Zheng Kou, and Kanghong Hu

The Ebola virus belongs to the Filovirus family, which causes Ebola hemorrhagic fever (mortality, 25%-90%). An outbreak of infection by the Ebola virus is sweeping across West Africa, leading to high mortality and worldwide panic. The Ebola virus has caused a serious threat to public health, so intensive scientific studies have been carried out. Several vaccines (e.g., rVSV-ZEBOV, ChAd3-ZEBOV) have been put into clinical trials and antiviral drugs (e.g., TKM-Ebola, ZMAPP) have been administered in the emergency setting to patients infected by the Ebola virus. Here, recent advances in vaccines and drugs against the Ebola virus are reviewed.

UI	MeSH Term	Description	Entries
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000998	Antiviral Agents	Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.	Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D046129	Ebola Vaccines	Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.	Ebola Vaccine,Ebola Virus Vaccine,Ebola Virus Vaccines,Ebolavirus Vaccine,Ebolavirus Vaccines,Vaccine, Ebola,Vaccine, Ebola Virus,Vaccine, Ebolavirus,Vaccines, Ebola,Vaccines, Ebola Virus,Vaccines, Ebolavirus,Virus Vaccine, Ebola,Virus Vaccines, Ebola
D019142	Hemorrhagic Fever, Ebola	A highly fatal, acute hemorrhagic fever caused by EBOLAVIRUS.	Ebola Hemorrhagic Fever,Ebola Virus Disease,Ebolavirus Infection,Ebola Infection,Ebola Virus Infection,Ebolavirus Infections,Infection, Ebola,Infection, Ebola Virus,Infection, Ebolavirus,Infections, Ebolavirus,Virus Infection, Ebola
D029043	Ebolavirus	A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.	Cote d'Ivoire ebola virus,Ebola Virus, Cote d'Ivoire,Ebola Virus, Reston,Ebola Virus, Sudan,Ebola Virus, Zaire,Ebola Virus,Ebola-like Viruses,Reston Ebola Virus,Sudan Ebola Virus,Zaire Ebola Virus,Ebola Viruses,Ebola like Viruses,Ebola-like Virus,Ebolaviruses,Virus, Ebola,Viruses, Ebola