Biomaterial Database

Recent Advances in Zika Virus Vaccines. 2018

Himanshu Garg, and Tugba Mehmetoglu-Gurbuz, and Anjali Joshi

Center of Emphasis in Infectious Diseases, Department of Biomedical Science, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA. himanshu.garg@ttuhsc.edu.

The recent outbreaks of Zika virus (ZIKV) infections and associated microcephaly in newborns has resulted in an unprecedented effort by researchers to target this virus. Significant advances have been made in developing vaccine candidates, treatment strategies and diagnostic assays in a relatively short period of time. Being a preventable disease, the first line of defense against ZIKV would be to vaccinate the highly susceptible target population, especially pregnant women. Along those lines, several vaccine candidates including purified inactivated virus (PIV), live attenuated virus (LAV), virus like particles (VLP), DNA, modified RNA, viral vectors and subunit vaccines have been in the pipeline with several advancing to clinical trials. As the primary objective of Zika vaccination is the prevention of vertical transmission of the virus to the unborn fetus, the safety and efficacy requirements for this vaccine remain unique when compared to other diseases. This review will discuss these recent advances in the field of Zika vaccine development.

UI	MeSH Term	Description	Entries
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D004353	Drug Evaluation, Preclinical	Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.	Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071243	Zika Virus Infection	A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	Congenital Zika Syndrome,Congenital Zika Virus Infection,Fever, Zika,ZikV Infection,Zika Fever,Zika Virus Disease,Disease, Zika Virus,Infection, ZikV,Infection, Zika Virus,Virus Disease, Zika,Virus Infection, Zika
D000071244	Zika Virus	An arbovirus in the FLAVIVIRUS genus of the family FLAVIVIRIDAE. Originally isolated in the Zika Forest of UGANDA it has been introduced to Asia and the Americas.	Virus, Zika,ZikV
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014765	Viral Vaccines	Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.	Viral Vaccine,Vaccine, Viral,Vaccines, Viral
D055808	Drug Discovery	The process of finding chemicals for potential therapeutic use.	Drug Prospecting,Discovery, Drug,Prospecting, Drug
D018562	Disease Transmission, Infectious	The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).	Close-Contact Infectious Disease Transmission,Close-Contact Transmission,Community Spread,Community Transmission,Disease Superspreader Event,Disease Superspreading,Droplet Transmission of Infectious Disease,Droplet Transmission, Infectious Disease,Infectious Disease Droplet Transmission,Person-to-Person Transmission,Autochthonous Transmission,Communicable Disease Transmission,Horizontal Transmission of Infection,Horizontal Transmission of Infectious Disease,Infection Transmission,Infection Transmission, Horizontal,Infectious Disease Transmission,Infectious Disease Transmission, Horizontal,Pathogen Transmission,Pathogen Transmission, Horizontal,Transmission of Infectious Disease,Transmission, Infectious Disease,Autochthonous Transmissions,Close Contact Infectious Disease Transmission,Close Contact Transmission,Close-Contact Transmissions,Community Transmissions,Disease Superspreader Events,Disease Superspreadings,Disease Transmission, Communicable,Event, Disease Superspreader,Events, Disease Superspreader,Infection Horizontal Transmission,Person to Person Transmission,Superspreader Event, Disease,Superspreader Events, Disease,Superspreading, Disease,Superspreadings, Disease,Transmission, Autochthonous,Transmission, Close-Contact,Transmission, Communicable Disease,Transmission, Infection,Transmission, Pathogen,Transmission, Person-to-Person,Transmissions, Autochthonous,Transmissions, Community