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The present study evaluates the effect of atropine and of the cholecystokinin receptor antagonist loxiglumide on feedback regulation of basal pancreatic secretion in 6 healthy volunteers. The intraduodenal instillation of the protease inhibitor camostate reduced enzymatic activities of trypsin and chymotrypsin by 80%. This was accompanied by a strong increase in amylase and lipase output. The intravenous infusion of atropine (5 micrograms/kg.h) completely abolished the stimulatory effect of camostate on enzyme output. The infusion of loxiglumide (10 mg/kg.h) caused no changes in camostate-induced stimulation of enzyme output. Plasma levels of cholecystokinin were not altered after intraduodenal instillation of camostate whether atropine, loxiglumide, or saline were infused. We suggest that the protease inhibitor camostate, by inhibition of the enzymatic activity of trypsin and chymotrypsin, interferes with feedback regulation of basal pancreatic secretion in humans, and this mechanism is predominantly mediated by the cholinergic system.
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
July 1990,
Scandinavian journal of gastroenterology,
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
June 1994,
Digestive diseases and sciences,
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
January 1990,
Digestion,
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
April 1995,
Pancreas,
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
October 1997,
Pancreas,
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
April 1992,
International journal of pancreatology : official journal of the International Association of Pancreatology,
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
March 1984,
Regulatory peptides,
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
January 1999,
Digestion,
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
March 1990,
The Journal of clinical investigation,
G Adler, and
M Reinshagen, and
I Koop, and
B Göke, and
A Schafmayer, and
L C Rovati, and
R Arnold
May 1991,
Human & experimental toxicology,
