Lack of Reproductive Toxicity in Adult Male Rats Exposed to Interferon-Alpha. 2015

Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
a Laboratory of Biology and Toxicology of Reproduction and Development, Department of Morphology , Institute of Biosciences, UNESP-Universidade Estadual Paulista , Botucatu , São Paulo , Brazil.

Interferon-alpha (IFN- α), a type I IFN, is a protein with antiviral, antiproliferative, and immunoregulatory activities, widely used in the treatment of several types of cancers as well as hepatitis B and C. Decrease of libido and erectile dysfunction are commonly reported by male patients during treatment of chronic hepatitis C with IFN- α . However, IFN therapy-associated underlying factors attributed to sexual dysfunction are still not well defined. Currently, there are few studies investigating the effects of IFN on male reproductive system functions. Given that, the aim of the present investigation was to examine effects of subchronic exposure to IFN- α (5 × 10(4) U/kg and 10 × 10(4) U/kg, 30 d) on serum hormones, sperm parameters, fertility, and testicular and epididymal hystopathology and morphometry in adult male Wistar rats. None of the evaluated parameters was markedly altered by IFN- α . Thus, our results suggest that exposure to IFN- α , in this experimental design, did not adversely affect sperm quality and fertile capacity of male rats.

UI MeSH Term Description Entries
D008297 Male Males
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D012098 Reproduction The total process by which organisms produce offspring. (Stedman, 25th ed) Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004822 Epididymis The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
D005298 Fertility The capacity to conceive or to induce conception. It may refer to either the male or female. Fecundity,Below Replacement Fertility,Differential Fertility,Fecundability,Fertility Determinants,Fertility Incentives,Fertility Preferences,Fertility, Below Replacement,Marital Fertility,Natural Fertility,Subfecundity,World Fertility Survey,Determinant, Fertility,Determinants, Fertility,Fertility Determinant,Fertility Incentive,Fertility Preference,Fertility Survey, World,Fertility Surveys, World,Fertility, Differential,Fertility, Marital,Fertility, Natural,Preference, Fertility,Preferences, Fertility,Survey, World Fertility,Surveys, World Fertility,World Fertility Surveys
D006728 Hormones Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects. Hormone,Hormone Receptor Agonists,Agonists, Hormone Receptor,Receptor Agonists, Hormone
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D013094 Spermatozoa Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility. Sperm,Spermatozoon,X-Bearing Sperm,X-Chromosome-Bearing Sperm,Y-Bearing Sperm,Y-Chromosome-Bearing Sperm,Sperm, X-Bearing,Sperm, X-Chromosome-Bearing,Sperm, Y-Bearing,Sperm, Y-Chromosome-Bearing,Sperms, X-Bearing,Sperms, X-Chromosome-Bearing,Sperms, Y-Bearing,Sperms, Y-Chromosome-Bearing,X Bearing Sperm,X Chromosome Bearing Sperm,X-Bearing Sperms,X-Chromosome-Bearing Sperms,Y Bearing Sperm,Y Chromosome Bearing Sperm,Y-Bearing Sperms,Y-Chromosome-Bearing Sperms

Related Publications

Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
August 2001, Human & experimental toxicology,
Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
January 2010, Wei sheng yan jiu = Journal of hygiene research,
Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
February 2016, Molecular reproduction and development,
Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
November 2009, Wei sheng yan jiu = Journal of hygiene research,
Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
November 2006, Reproductive toxicology (Elmsford, N.Y.),
Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
January 2007, Reproductive toxicology (Elmsford, N.Y.),
Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
November 2018, Toxicology research,
Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
April 2006, Pharmacology, biochemistry, and behavior,
Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
May 1996, Human & experimental toxicology,
Josiane de Lima Rosa, and Marilia Martins Cavariani, and Cibele dos Santos Borges, and Gabriel Adan Araújo Leite, and Janete Aparecida Anselmo-Franci, and Wilma De Grava Kempinas
July 2006, Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,
Copied contents to your clipboard!