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The present study involves the design and synthesis of naphthoflavones as antiproliferative agents. The strategy presents naphthoflavones as hybrids of naphthyl based chalcones and flavones. A panel of human cancer cell lines were employed for the cytotoxicity studies. DK-13 exhibited significant cytoxicity against MiaPaCa-2 cell lines with IC50 value of 1.93 μM and 5.63 μM against MCF-7 cell lines. The compound DK-13 was found to induce apoptosis evidenced through phase contrast microscopy, DAPI staining, and mitochondrial membrane potential loss. The cell phase distribution studies indicated an increase from 11.26 % (control sample) to 55.19 % (sample treated with 20 μM compound DK-13) in the apoptotic population.
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
May 2021,
ChemMedChem,
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
November 2014,
Molecules (Basel, Switzerland),
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
May 2014,
The Journal of steroid biochemistry and molecular biology,
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
December 2019,
Steroids,
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
October 2019,
Steroids,
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
July 2023,
Pharmaceuticals (Basel, Switzerland),
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
November 2020,
Molecules (Basel, Switzerland),
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
November 2019,
Chemical & pharmaceutical bulletin,
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
October 2019,
Bioorganic chemistry,
Dinesh Kumar, and
Onkar Singh, and
Kunal Nepali, and
Pms Bedi, and
Arem Qayum, and
Shashank Singh, and
Subheet K Jain
August 2017,
MedChemComm,
