Biomaterial Database

[The use of soft-ionization mass-spectrometry in biochemistry]. 1989

L F Sukhodub

Basic principles of mass spectrometry (MS) and methods of ionization are described. Methodological aspects of field ionization (FI) and field desorption (FD) MS are considered in detail. Examples are given demonstrating application of FI and FD MS as an analytical tool for structure analysis and identification of mono-, di- and oligosaccharides, nucleic acid bases, nucleosides, nucleotides, oligonucleotides, biomacromolecules (DNA, polysaccharides), microorganisms, metals in biological tissues and liquids, drugs (in particular, organophosphoric compounds) and their metabolites. The possibilities of fast atom bombardment MS in the investigation of dGuo and DNA alkylation by thiophosphamide are demonstrated.

UI	MeSH Term	Description	Entries
D007477	Ions	An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.
D008670	Metals	Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)	Metal
D009696	Nucleic Acids	High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.	Nucleic Acid,Acid, Nucleic,Acids, Nucleic
D004364	Pharmaceutical Preparations	Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.	Drug,Drugs,Pharmaceutical,Pharmaceutical Preparation,Pharmaceutical Product,Pharmaceutic Preparations,Pharmaceutical Products,Pharmaceuticals,Preparations, Pharmaceutical,Preparation, Pharmaceutical,Preparations, Pharmaceutic,Product, Pharmaceutical,Products, Pharmaceutical
D013058	Mass Spectrometry	An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.	Mass Spectroscopy,Spectrometry, Mass,Spectroscopy, Mass,Spectrum Analysis, Mass,Analysis, Mass Spectrum,Mass Spectrum Analysis,Analyses, Mass Spectrum,Mass Spectrum Analyses,Spectrum Analyses, Mass