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The results obtained using three different soft ionization techniques (field desorption (FD), fast atom bombardment (FAB) and desorption chemical ionization (DCI] on the antiviral antibiotic distamycin and on some analogues are reported. FAB mass spectra show more intense molecular ion and more regular fragmentation while FD and DCI mass spectra are dominated by thermally originated fragments. Information furnished by the three systems are different and complementary.
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