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Serial coagulation studies were performed in 26 pediatric patients with acute lymphoblastic leukemia during initial induction therapy with vincristine, prednisone, and L-asparaginase. Prolongation of screening coagulation tests was frequent: prothrombin time (in 16 of 26 patients), partial thromboplastin time (23/26) and thrombin time (21/26). In all 26 patients fibrinogen levels fell below .20 g/100 ml and 16 had levels below .10 g/100 ml. Sixteen patients had plasma coagulation factor assays performed. In these 16 patients, Factor XI was less than 40% in 14 and Factor XI was less than 70% in 9, with only a few scattered low levels of other factors. There were no clinical bleeding episodes. Coagulation abnormalities returned to normal at the completion of L-asparaginase therapy while the patients remained on vincristine and prednisone.
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
May 1986,
The Journal of pediatrics,
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
June 1982,
The Journal of pediatrics,
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
August 2008,
Thrombosis and haemostasis,
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
April 2024,
International journal of hematology,
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
January 2022,
Leukemia research reports,
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
July 2012,
Journal of pharmacology & pharmacotherapeutics,
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
June 2021,
Thrombosis journal,
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
January 1994,
Gematologiia i transfuziologiia,
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
March 2004,
Cancer chemotherapy and pharmacology,
N K Ramsay, and
P F Coccia, and
W Krivit, and
M E Nesbit, and
J R Edson
February 2022,
Clinical laboratory,
