-transparent.png){kind=logo}
Increased plasma levels of platelet-derived growth factor activity in patients with progressive systemic sclerosis. 1989
Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, S. Maria Imbaro, Italy.
We measured mitogenic activity of whole blood serum and platelet-poor plasma-derived serum of a group of 10 patients with progressive systemic sclerosis and of 8 controls. Mitogenic activity of plasma-derived serum was greater in patients than in controls, in the absence of other signs of platelet activation. This increased activity was inhibited by specific antibodies, anti-platelet derived growth factor, suggesting that circulating levels of platelet-derived growth factor may be present in progressive systemic sclerosis patients. Platelet-derived growth factor, released either by platelets or by monocytes, might play a role in the pathogenesis of scleroderma.
Related Publications
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
October 1990,
Arthritis and rheumatism,
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
April 1999,
The Journal of rheumatology,
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
August 1991,
Cancer research,
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
February 2005,
Acta orthopaedica,
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
December 1978,
Bollettino della Societa italiana di biologia sperimentale,
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
January 1991,
British journal of haematology,
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
October 1998,
American journal of hypertension,
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
January 2000,
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
April 2009,
Arthritis and rheumatism,
A Pandolfi, and
M Florita, and
G Altomare, and
P Pigatto, and
M B Donati, and
A Poggi
March 1992,
The British journal of dermatology,
