BIOMAT Database Logo BIOMAT Database Logo

Chemical Exacerbation of Light-induced Retinal Degeneration in F344/N Rats in National Toxicology Program Rodent Bioassays. 2016

Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, USA Taisho Pharmaceutical Co. Ltd., Saitama, Japan.

Retinal degeneration due to chronic ambient light exposure is a common spontaneous age-related finding in albino rats, but it can also be related to exposures associated with environmental chemicals and drugs. Typically, light-induced retinal degeneration has a central/hemispherical localization whereas chemical-induced retinal degeneration has a diffuse localization. This study was conducted to identify and characterize treatment-related retinal degeneration in National Toxicology Program rodent bioassays. A total of 3 chronic bioassays in F344/N rats (but not in B6C3F1/N mice) were identified that had treatment-related increases in retinal degeneration (kava kava extract, acrylamide, and leucomalachite green). A retrospective light microscopic evaluation of the retinas from rats in these 3 studies showed a dose-related increase in the frequencies of retinal degeneration, beginning with the loss of photoreceptor cells, followed by the inner nuclear layer cells. These dose-related increased frequencies of degenerative retinal lesions localized within the central/hemispherical region are suggestive of exacerbation of light-induced retinal degeneration.

UI MeSH Term Description Entries
D008027 Light That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range. Light, Visible,Photoradiation,Radiation, Visible,Visible Radiation,Photoradiations,Radiations, Visible,Visible Light,Visible Radiations
D011916 Rats, Inbred F344 An inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes. Fischer Rats,Rats, Inbred CDF,Rats, Inbred Fischer 344,Rats, F344,Rats, Inbred Fisher 344,CDF Rat, Inbred,CDF Rats, Inbred,F344 Rat,F344 Rat, Inbred,F344 Rats,F344 Rats, Inbred,Inbred CDF Rat,Inbred CDF Rats,Inbred F344 Rat,Inbred F344 Rats,Rat, F344,Rat, Inbred CDF,Rat, Inbred F344,Rats, Fischer
D012162 Retinal Degeneration A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304) Degeneration, Retinal,Degenerations, Retinal,Retinal Degenerations
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012394 Rosaniline Dyes Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS. Fuchsins,Magentas,Fuchsin,Triphenylmethane Aniline Compounds,Aniline Compounds, Triphenylmethane,Compounds, Triphenylmethane Aniline,Dyes, Rosaniline
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D020106 Acrylamide A colorless, odorless, highly water soluble vinyl monomer formed from the hydration of acrylonitrile. It is primarily used in research laboratories for electrophoresis, chromatography, and electron microscopy and in the sewage and wastewater treatment industries.
D020901 Kava Dried rhizome and roots of Piper methysticum, a shrub native to Oceania and known for its anti-anxiety and sedative properties. Heavy usage results in some adverse effects. It contains ALKALOIDS; LACTONES; kawain, methysticin, mucilage, STARCH, and yangonin. Kava is also the name of the pungent beverage prepared from the plant's roots. Piper methysticum,Kava Kava,Kawa,Kawa Kawa,Kava Kavas,Kava, Kava,Kavas,Kavas, Kava,Kawa Kawas,Kawa, Kawa,Kawas,Kawas, Kawa,Piper methysticums,methysticums, Piper

Related Publications

Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Workgroup report: National Toxicology Program workshop on Hormonally Induced Reproductive Tumors - Relevance of Rodent Bioassays.
September 2007, Environmental health perspectives,
Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Gender differences in chemical carcinogenesis in National Toxicology Program 2-year bioassays.
December 2012, Toxicologic pathology,
Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies.
January 1999, Toxicologic pathology,
Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Prospective ke screening of potential carcinogens being tested in rodent bioassays by the US National Toxicology Program.
March 1992, Mutagenesis,
Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Immunohistochemical investigation of F344/N rat islet cell tumors from national toxicology program studies.
July 2012, Toxicologic pathology,
Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Reproductive toxicology of methyldopa in male F344/N rats.
November 1986, Toxicology,
Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Intense cyclic light-induced retinal degeneration in rats.
February 2010, Archives of ophthalmology (Chicago, Ill. : 1960),
Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Ocular thrombosis and retinal degeneration induced in female F344 rats by 2-butoxyethanol.
September 1999, Human & experimental toxicology,
Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Prediction of the outcome of rodent carcinogenicity bioassays currently being conducted on 44 chemicals by the National Toxicology Program.
January 1990, Mutagenesis,
Haruhiro Yamashita, and Mark J Hoenerhoff, and Shyamal D Peddada, and Robert C Sills, and Arun R Pandiri
Nimodipine rescues N-methyl-N-nitrosourea-induced retinal degeneration in rats.
April 2013, Pharmacognosy magazine,
Copied contents to your clipboard!