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Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease. 1989
N C Lan, and
C Heinzmann, and
A Gal, and
I Klisak, and
U Orth, and
E Lai, and
J Grimsby, and
R S Sparkes, and
T Mohandas, and
J C Shih
Division of Biological Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033.
Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to each other and to the DXS7 locus (Xp 11.3).
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