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In order to determine if thyroid disease in hypogonadal men is the result of chronic elevation of serum gonadotropins, thyroid histology and serum thyroid hormone levels were evaluated in male rats that had been castrated either 2 weeks or 15 months previously. Despite significantly elevating serum LH levels, castration did not affect thyroid structure or function. Serum total T4 levels were reduced with age in both short and long-term castrate animals but returned to the levels seen in young rats when testosterone was replaced. Testosterone replacement also increased free T4 levels in both the young and old castrate rats. Neither age nor testosterone replacement affected serum T3 or TSH levels.
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
June 2002,
Toxicological sciences : an official journal of the Society of Toxicology,
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
May 1996,
Bulletin of environmental contamination and toxicology,
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
January 1980,
Journal of nutritional science and vitaminology,
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
January 1955,
Annales d'endocrinologie,
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
January 1993,
Neuroendocrinology,
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
November 1983,
Archives of toxicology,
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
January 1952,
Archiv fur Dermatologie und Syphilis,
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
October 1989,
The Journal of pharmacy and pharmacology,
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
January 1995,
Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology,
R W Steger, and
V Chandrashekar, and
A Bartke, and
J Wortsman, and
S C Newton, and
R C Smallridge, and
J Dietrich
March 1966,
Journal of applied physiology,
