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The effects of neuropeptide Y (NPY) and related peptide fragments on blood pressure and vagal action at the heart were compared in the anaesthetized rat. A change in vagal action was taken as a measure of presynaptic activity and a change in blood pressure was taken as a measure of postsynaptic activity. NPY, NPY-(13-36), PYY-(13-36), des-Ser22-NPY-(13-36) and a stabilized 13-36 analogue of NPY (ANA NPY) all exerted pressor actions and attenuated vagal action at the heart. The maximum vagal inhibitory or presynaptic action in order of potency was NPY, ANA-NPY, PYY-(13-36) significantly greater than NPY-(13-36), des-Ser22-NPY-(13-36). The order of potency for the half time of this effect was NPY, ANA-NPY significantly longer than PYY-(13-36) and NPY-(13-36), which were significantly longer than des Ser22-NPY-(13-36). For the pressor or postsynaptic effects, NPY increased blood pressure significantly more and for a longer duration than all the 13-36 fragments, which were not demonstrably different in this respect. These results are consistent with the proposal that there are two populations of NPY receptors. The C-terminal flanking peptide of NPY (CPON) and desamido-NPY had no effect on either vagal action at the heart or on blood pressure.
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
January 1991,
European journal of pharmacology,
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
April 1987,
European journal of pharmacology,
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
February 1986,
Acta physiologica Scandinavica,
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
May 1988,
Clinical and experimental pharmacology & physiology,
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
November 1993,
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology,
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
February 1986,
Regulatory peptides,
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
June 1996,
Brain research,
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
January 1986,
Medical biology,
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
April 1996,
Histology and histopathology,
E K Potter, and
L Mitchell, and
M J McCloskey, and
A Tseng, and
A E Goodman, and
J Shine, and
D I McCloskey
October 1985,
Regulatory peptides,
