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Gene conversion is one mechanism of antigenic variation in Trypanosoma brucei. Variant surface glycoprotein (VSG) genes are duplicated by this process to telomeric locations from which they may be expressed. We examined four independent antigenic switches in which the IsTaR 1.1 minichromosomal VSG gene is duplicated to a large chromosome where it is expressed. An unusual feature of three of these telomeric gene conversions is that the distance between the VSG gene and the end of the chromosome is identical for both the basic and duplicated copies following the antigenic switch. This suggests that the gene conversion is initiated 5' to the VSG gene and extends to the end of the telomere. The data also suggest that events other than simple nucleotide addition account for telomeric growth.
J K Scholler, and
P J Myler, and
K D Stuart
January 1989,
Experimental parasitology,
J K Scholler, and
P J Myler, and
K D Stuart
March 1985,
Molecular and cellular biology,
J K Scholler, and
P J Myler, and
K D Stuart
February 1984,
Cell,
J K Scholler, and
P J Myler, and
K D Stuart
January 2008,
PloS one,
J K Scholler, and
P J Myler, and
K D Stuart
September 1988,
Gene,
J K Scholler, and
P J Myler, and
K D Stuart
November 1995,
Cell,
J K Scholler, and
P J Myler, and
K D Stuart
May 1984,
Nucleic acids research,
J K Scholler, and
P J Myler, and
K D Stuart
December 1997,
Genes & development,
J K Scholler, and
P J Myler, and
K D Stuart
February 2007,
Molecular microbiology,
J K Scholler, and
P J Myler, and
K D Stuart
December 1985,
Molecular and biochemical parasitology,
