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An HIV-infected Pregnant Woman Treated with the Long-term Administration of Antiretroviral Therapy Including Raltegravir. 2016
Kenichiro Yaita, and
Shigeru Inoue, and
Takashi Horinouchi, and
Masahiro Kinoshita, and
Mitsuaki Unno, and
Osuke Iwata, and
Yuhei Tanaka, and
Kenji Gotoh, and
Mikio Ishibashi, and
Yoshiro Sakai, and
Kenji Masunaga, and
Hiroshi Watanabe, and
Masaki Tominaga
Department of Infection Control and Prevention, Kurume University School of Medicine, Japan.
A 27-year-old HIV-infected pregnant Japanese woman was admitted to our hospital at gestational week 14. The patient's HIV viral load was 71,000 copies/mL, and her CD4 cell count was 147 cells/mm(3). Zidovudine, lamivudine, and lopinavir/ritonavir were administered at gestational week 18. Because the viral load increased to 222,000 copies/mL at the initiation of antiretroviral therapy, we added raltegravir. The decrease in the viral load was satisfactory, and a caesarean delivery was performed. Although the plasma concentration of raltegravir in the neonate was significantly high (2,482 ng/mL), no adverse event was confirmed. There was no evidence of the mother-to-child transmission of HIV.
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