BIOMAT Database Logo BIOMAT Database Logo

Changes in vascularity of liver tumours after hepatic arterial embolization with degradable starch microspheres. 1989

D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
Istituto di Patologia Chirurgica dell'Università, Genova, Italy.

The role of vascularity as a prognostic factor was investigated in 35 patients undergoing arterial chemotherapy for liver tumours. Compared with parenchyma, tumour vascularity was classified as hot (18 cases), cold (12 cases), and mixed (12 cases) using 99mTc-macroaggregated albumin (MAA) hepatic arterial scans. The proportion of patients showing complete and partial responses to treatment was higher in the hot group (56 per cent) than in the combined cold and mixed group (12 per cent). In 15 cases (six hot, six cold and three mixed lesions), additional MAA scans were performed immediately after arterial embolization with degradable starch microspheres (DSMs). Either complete or partial reversal of tumour vascularity was observed after DSM-embolization in five and seven cases respectively, two and two of them respectively showing native cold lesions. As tumour vascularity appears to be a prominent prognostic factor, DSM-embolization should improve the efficacy of treatment by improving liver extraction of drugs and causing flow redistribution towards hypovascular areas.

UI MeSH Term Description Entries
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008102 Liver Circulation The circulation of BLOOD through the LIVER. Hepatic Circulation,Circulation, Liver,Circulation, Hepatic
D008113 Liver Neoplasms Tumors or cancer of the LIVER. Cancer of Liver,Hepatic Cancer,Liver Cancer,Cancer of the Liver,Cancer, Hepatocellular,Hepatic Neoplasms,Hepatocellular Cancer,Neoplasms, Hepatic,Neoplasms, Liver,Cancer, Hepatic,Cancer, Liver,Cancers, Hepatic,Cancers, Hepatocellular,Cancers, Liver,Hepatic Cancers,Hepatic Neoplasm,Hepatocellular Cancers,Liver Cancers,Liver Neoplasm,Neoplasm, Hepatic,Neoplasm, Liver
D008297 Male Males
D008863 Microspheres Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers. Latex Beads,Latex Particles,Latex Spheres,Microbeads,Bead, Latex,Beads, Latex,Latex Bead,Latex Particle,Latex Sphere,Microbead,Microsphere,Particle, Latex,Particles, Latex,Sphere, Latex,Spheres, Latex
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D004621 Embolization, Therapeutic A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage. Embolotherapy,Therapeutic Embolization,Embolizations, Therapeutic,Embolotherapies,Therapeutic Embolizations
D005260 Female Females

Related Publications

D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
Liver microcirculation after hepatic artery embolization with degradable starch microspheres in vivo.
July 2006, World journal of gastroenterology,
D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
Increasing hepatic arterial flow to hypovascular hepatic tumours using degradable starch microspheres.
April 1996, British journal of cancer,
D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
Combined effects of hepatic arterial embolization using degradable starch microspheres (DSM) in hyperthermia for liver cancer.
January 1991, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
[Experimental study of normal liver regeneration in hepatic arterial infusion with degradable starch microspheres (DSM)].
April 1989, Gan to kagaku ryoho. Cancer & chemotherapy,
D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
Temporary arterial embolization of liver parenchyma with degradable starch microspheres (EmboCept®S) in a swine model.
April 2015, Cardiovascular and interventional radiology,
D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
[Assessment of therapeutic effects by transcatheter arterial embolization (TAE) in hepatic malignant tumors with degradable starch microspheres (DSM)].
August 1988, Gan to kagaku ryoho. Cancer & chemotherapy,
D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
Feasibility of temporary protective embolization of normal liver tissue using degradable starch microspheres during radioembolization of liver tumours.
February 2014, European journal of nuclear medicine and molecular imaging,
D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
[Hepatic arterial infusion of degradable starch microspheres (DSM) with adriamycin or mitomycin C in liver cancer].
August 1988, Gan to kagaku ryoho. Cancer & chemotherapy,
D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
[Transcatheter hepatic arterial embolization therapy using degradable polylactic acid microspheres].
October 1985, Gan to kagaku ryoho. Cancer & chemotherapy,
D Civalleri, and G Scopinaro, and N Balletto, and F Claudiani, and F De Cian, and F DeCian, and G Camerini, and M DePaoli, and U Bonalumi
[Intermittent arterial chemoembolization in liver tumor using degradable starch microspheres].
August 1990, Gan to kagaku ryoho. Cancer & chemotherapy,
Copied contents to your clipboard!