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Transcatheter hepatic arterial embolization therapy (TAE) is an established method for the treatment of hepatocellular carcinoma (HCC). We have developed a new embolus consisting of microspheres with a mean diameter of about 200 microns which are composed of biodegradable polymolecular polylactic and the anti-cancer agent, aclarubicin -HCl, in a ratio of 12% w/w. These microspheres were applied to 28 patients with inoperable HCC using the following method microspheres containing 50 mg of aclarubicin-HCl were injected through a catheter placed in the hepatic artery or one of its branches, 2 or 3 times at intervals of 2 to 4 weeks. The effectiveness was confirmed by decreased levels of serum AFP and regression of the tumor size, and the accumulated survival rate for 6 months was 83.3%.
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
January 2003,
Radiation medicine,
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
August 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
October 2000,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
April 1989,
Nihon Gan Chiryo Gakkai shi,
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
January 1991,
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group,
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
September 2004,
Biomaterials,
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
April 1996,
British journal of cancer,
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
July 1989,
The British journal of surgery,
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
January 1977,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
T Ichihara, and
M Akagi, and
K Mori, and
S Ikei, and
K Sakamoto, and
S Katauchi, and
T Beppu, and
M Nokano, and
K Tuni
January 1981,
Rinsho hoshasen. Clinical radiography,
