Bioactive composites containing TEGDMA-functionalized calcium phosphate particles: Degree of conversion, fracture strength and ion release evaluation. 2016

Yvette Alania, and Marina D S Chiari, and Marcela C Rodrigues, and Victor E Arana-Chavez, and Ana Helena A Bressiani, and Flavio M Vichi, and Roberto R Braga
Department of Biomaterials and Oral Biology, University of São Paulo, School of Dentistry, Av. Prof. Lineu Prestes 2227, São Paulo, SP 05508-000, Brazil.

To evaluate the strength and ion release of experimental composites containing TEGDMA-functionalized calcium phosphate particles. Seven composites containing equal parts (in mols) of BisGMA and TEGDMA and 60vol% of fillers were manipulated. Filler phase was constituted by silanized barium glass and 0% (control), 10% or 20% (volume) of dicalcium phosphate dihydrate (DPCD) particles, either non-functionalized or functionalized with two different TEDGMA contents. DCPD particles were synthesized and characterized by X-ray diffraction (XRD), elemental analysis, surface area and dynamic light scattering. Composites were tested for degree of conversion (DC) by near-FTIR. Biaxial flexural strength (BFS) was determined after 24h and 28days in water. Calcium and phosphate release after 7days was assessed using inductively coupled plasma optical emission spectrometry (ICP-OES). Data were analyzed by ANOVA/Tukey test (alpha:5%). XRD confirmed the crystalline structure corresponding to DCPD. Elemental analysis revealed particles with zero, 14% or 22% TEGDMA, with similar D50 (around 19μm) and surface areas from 3.5 to 11.4m2/g. The presence of DCPD did not reduce DC. After 24h, functionalization (both 14% and 22% TEGDMA) improved composite strength in comparison to non-functionalized DCPD, both at 10% and 20% levels. After 28days, BFS of materials containing 10% functionalized DCPD were statistically similar to the control containing only barium glass. Among composites containing 10% DCPD, particle functionalization with 14% TEGDMA did not jeopardize ion release. At 10vol%, the use of TEGDMA-functionalized CaP particles improved composite strength in relation to non-functionalized particles, while maintaining similar ion release levels.

UI MeSH Term Description Entries
D008422 Materials Testing The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility. Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D011092 Polyethylene Glycols Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS. Macrogols,Polyoxyethylenes,Carbowax,Macrogol,Polyethylene Glycol,Polyethylene Oxide,Polyethyleneoxide,Polyglycol,Glycol, Polyethylene,Glycols, Polyethylene,Oxide, Polyethylene,Oxides, Polyethylene,Polyethylene Oxides,Polyethyleneoxides,Polyglycols,Polyoxyethylene
D011109 Polymethacrylic Acids Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer. Methacrylic Acid Polymers,Acid Polymers, Methacrylic,Acids, Polymethacrylic,Polymers, Methacrylic Acid
D002130 Calcium Phosphates Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements. Phosphates, Calcium
D003188 Composite Resins Synthetic resins, containing an inert filler, that are widely used in dentistry. Composite Resin,Resin, Composite,Resins, Composite
D003764 Dental Materials Materials used in the production of dental bases, restorations, impressions, prostheses, etc. Dental Material,Material, Dental,Materials, Dental
D017438 Bisphenol A-Glycidyl Methacrylate The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials. Bis-GMA,Bis-GMA Polymer,2-Propenoic acid, 2-methyl-, (1-methylethylidene)bis(4,1-phenyleneoxy(2-hydroxy-3,1-propanediyl)) ester, homopolymer,Adaptic,Bis(Phenol A-Glycidyl Methacrylate),Bis(Phenol A-Glycidyl Methacrylate), Homopolymer,Bis(Phenol A-Glycydyl Methacrylate),Bis-GMA Resin,Bisphenol A-Glycidyl Methacrylate Homopolymer,Bisphenol A-Glycidyl Methacrylate Polymer,Concise Composite Resin,Concise Enamel Bond,Concise Enamel Bond System,Concise Resin,Concise White Sealant,Conclude Composite Resin,Conclude Resin,Delton,Epoxylite-9075,Kerr Pit and Fissure Sealant,Kerr Sealer,Nuva-Seal,Panavia Opaque,Poly(Bis-GMA),Retroplast,Silux,Bis GMA,Bis GMA Polymer,Bis GMA Resin,Bis-GMA Polymers,Bis-GMA Resins,Bisphenol A Glycidyl Methacrylate,Bisphenol A Glycidyl Methacrylate Homopolymer,Bisphenol A Glycidyl Methacrylate Polymer,Bond, Concise Enamel,Composite Resin, Concise,Composite Resin, Conclude,Composite Resins, Concise,Concise Composite Resins,Concise Resins,Enamel Bond, Concise,Epoxylite 9075,Epoxylite9075,Methacrylate, Bisphenol A-Glycidyl,Nuva Seal,NuvaSeal,Opaque, Panavia,Polymer, Bis-GMA,Polymers, Bis-GMA,Resin, Bis-GMA,Resin, Concise,Resin, Concise Composite,Resin, Conclude,Resin, Conclude Composite,Resins, Bis-GMA,Resins, Concise,Resins, Concise Composite

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