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Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N',N'-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infection. CNS injuries were visualized in all cases, with highly intense contrasting at the expense of Mn-DCTA accumulation at the periphery of the damaged zone. Quantitative evaluation of the paramagnetic accumulation in the focus showed that the amplification index wa s 1.19±0.11 for the central areas and 1.47±0.17 for the peripheral ones. The pituitary (1.18±0.05) and vascular plexuses of the lateral ventricles (1.12±0.09) were also contrasted. Injection of the paramagnetic to dogs was not associated with any kinds of pathological or physiological reactions. Mn-DCTA complex allowed contrast visualization of the focal injuries to the CNS and could be regarded as a paramagnetic contrast agent for magnetic resonance imaging of brain injuries in dogs.
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
January 2000,
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association,
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
January 1999,
Bioconjugate chemistry,
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
May 1987,
Journal of neurosurgery,
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
January 2008,
Eksperimental'naia i klinicheskaia farmakologiia,
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
April 2022,
Nature communications,
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
October 1983,
Seminars in nuclear medicine,
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
July 2007,
Journal of inorganic biochemistry,
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
November 1996,
The Journal of urology,
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
November 1982,
Circulation,
W Yu Ussov, and
M L Belyanin, and
A I Bezlepkin, and
O Yu Borodin, and
E E Bobrikova, and
N L Shimanovskii
February 1991,
Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes,
