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Binding sites for prolactin were localized and quantified in the female rat brain by in vitro autoradiographic analysis with iodine-125-labeled ovine prolactin. Following incubation, labeled prolactin bound preferentially to the median eminence and choroid plexus of the lateral and third ventricles. The addition of excess unlabeled ovine prolactin blocked binding of the labeled hormone in the choroid plexus, and attenuated prolactin binding in the median eminence. These results provide evidence for median eminence. These results provide evidence for prolactin-specific recognition sites in the median eminence, a region intimately involved in the hypothalamic regulation of prolactin secretion.
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
January 1990,
Pharmacological research,
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
January 1980,
Experimental brain research,
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
January 1983,
Cell and tissue research,
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
February 1985,
Proceedings of the National Academy of Sciences of the United States of America,
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
June 1987,
Neuroendocrinology,
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
March 1980,
Science (New York, N.Y.),
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
January 1991,
Life sciences,
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
January 1982,
Annals of the New York Academy of Sciences,
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
January 1987,
The Anatomical record,
A C Barton, and
R A Lahti, and
M F Piercey, and
K E Moore
August 1986,
Endocrinology,
