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The present work examines the ability of prolactin to enter the CNS of the rat and effect its feedback stimulation of dopamine release prior to the appearance of prolactin receptors in choroid plexus (i.e., 10 days postnatal). An inhibitor of tyrosine hydroxylase was used to allow the assessment of dopamine turnover separate from synthesis and transport of the amine. Chronic but not acute hyperprolactinemia resulted in increased dopamine release relative to vehicle-treated controls, as shown by diminished fluorescence intensity in the median eminence. These results indicate that activation of the prolactin short-loop feedback system occurs by 10 days postnatal, prior to the appearance of prolactin receptors at the choroid plexus.
W F Silverman, and
R J Walsh
June 1978,
Life sciences,
W F Silverman, and
R J Walsh
June 1979,
Proceedings of the National Academy of Sciences of the United States of America,
W F Silverman, and
R J Walsh
July 1980,
Brain research,
W F Silverman, and
R J Walsh
January 1977,
Advances in biochemical psychopharmacology,
W F Silverman, and
R J Walsh
May 1981,
Brain research,
W F Silverman, and
R J Walsh
May 1985,
Endocrinology,
W F Silverman, and
R J Walsh
June 1989,
Neuroendocrinology,
W F Silverman, and
R J Walsh
May 1989,
Neuroendocrinology,
W F Silverman, and
R J Walsh
June 1985,
Neuroscience letters,
W F Silverman, and
R J Walsh
January 1977,
Brain research,
