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Spinal cord injury (SCI) causes functional impairment as a result of the initial injury followed by secondary injury mechanism. SCI provokes an inflammatory response that causes secondary tissue damage and neurodegeneration. While the use of neural stem cell (NSC) engraftment to mitigate secondary injury has been of interest to many researchers, it still faces several limitations. As such, we investigated if NSC-conditioned medium (NSC-M) possesses therapeutic potential for the treatment of SCI. It has been proposed that many of the beneficial effects attributed to stem cell therapies are due to secreted factors. Utilizing primary cell culture and murine models of SCI, we determined that systemic treatment with NSC-M was able to significantly improve motor function and lesion healing. In addition, NSC-M demonstrated significant anti-inflammatory potential in vitro and in vivo, reducing inflammatory cytokine expression in both activated macrophages and injured spinal cord tissues. NSC-M was also able to reduce the expression of inducible nitric oxide synthase (iNOS) within the spleen of injured animals, indicating an ability to reduce systemic inflammation. Thus, we believe that NSC-M offers a possible alternative to direct stem cell engraftment for the treatment of SCI.
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
January 2014,
Cell transplantation,
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
September 2022,
Spine surgery and related research,
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
May 2018,
Neural regeneration research,
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
July 2020,
International journal of molecular sciences,
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
August 2020,
Stem cells and development,
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
January 2020,
NPJ Regenerative medicine,
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
January 2017,
Brain research,
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
December 2009,
Journal of neurotrauma,
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
January 2018,
Developmental dynamics : an official publication of the American Association of Anatomists,
Zhijian Cheng, and
Dale B Bosco, and
Li Sun, and
Xiaoming Chen, and
Yunsheng Xu, and
Wenjiao Tai, and
Ruth Didier, and
Jinhua Li, and
Jianqing Fan, and
Xijing He, and
Yi Ren
December 2018,
Journal of clinical medicine,
