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Plasma concentrations of IGF-1 decrease markedly during starvation secondary to a reduction in somatotropic receptors in the liver. We investigated whether IGF-1 administration during starvation in mice inhibits the catabolic state normally observed. Plasma concentrations of IGF-1 in starved mice receiving IGF-1 therapy were similar to values from non-starved mice, whereas bGH treatment failed to increase plasma IGF-1 levels. The degree of weight loss during 36 hours of starvation was reduced (p less than 0.01) by frequent treatment with subcutaneous IGF-1 but not by bGH therapy. The effect was restricted to the period 28 to 36 hours after commencement of the fast. These results suggest that a fall in circulating IGF-1 may play a role in the metabolic adaptation during malnutrition.
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
October 2001,
Molecular pathology : MP,
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
January 1992,
Breast cancer research and treatment,
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
October 2002,
Journal of cardiovascular pharmacology and therapeutics,
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
August 1991,
Burns : journal of the International Society for Burn Injuries,
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
June 2002,
Bone,
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
May 2021,
The journal of international advanced otology,
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
November 1995,
Clinical and experimental immunology,
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
November 2007,
Ai zheng = Aizheng = Chinese journal of cancer,
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
February 1985,
Endocrinology,
U O'Sullivan, and
P D Gluckman, and
B H Breier, and
S Woodall, and
R A Siddiqui, and
S N McCutcheon
January 2016,
CellR4-- repair, replacement, regeneration, & reprogramming,
