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We have assessed the effects of intravenous infusion of bovine pancreatic polypeptide (PP) (1 microgram kg-1 h-1) on the basal and postprandial secretion of gastrointestinal, pancreatic and adrenocortical hormones in normal dogs. Bovine PP within the physiological range increased plasma cortisol levels transiently but significantly. PP elicited an inhibition of insulin response to a protein-rich meal, and tended to reduce the gastrin response. There were, however, no significant changes in basal or postprandial plasma concentrations of motilin and pancreatic glucagon during PP infusion. These results suggest that PP may have a role in controlling insulin secretion from the pancreas. The possible mechanisms are discussed mainly on the basis of vagal innervation.
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
February 1988,
Acta physiologica Scandinavica,
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
September 1991,
Diabetes research and clinical practice,
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
October 1982,
Canadian journal of physiology and pharmacology,
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
September 1990,
Surgery,
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
December 1979,
Endocrinology,
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
September 1990,
Digestive diseases and sciences,
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
January 1989,
Pancreas,
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
February 1983,
The Journal of clinical endocrinology and metabolism,
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
January 1980,
Scandinavian journal of gastroenterology. Supplement,
A Inui, and
T Inoue, and
N Sakatani, and
M Oya, and
H Morioka, and
T Ogawa, and
M Ishida, and
N Mizuno, and
M Oimomi, and
S Baba
January 1987,
Scandinavian journal of gastroenterology,
