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A high-resolution map for the arrangement of histones along DNA in the nucleosome core particle has been determined by a sequencing procedure based on crosslinking histones to the 5'-terminal DNA fragments produced by scission of one DNA strand at the point of crosslinking. The position of histones on DNA has been identified by measuring the length of crosslinked DNA fragments. The results demonstrate that each of the histones is arranged within several adjacent or dispersed DNA segments of a little less than 10 nucleotides in length. Histone-free intervals are located between these segments at the regular distances of about (10)n nucleotides from the 5' end of the DNA and are likely to face one side of the DNA helix. Histones appear to be arranged in a similar manner on both DNA strands and do not form "locks" around DNA. A linearized model of the core particle is proposed.
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
August 1978,
Proceedings of the National Academy of Sciences of the United States of America,
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
January 1988,
Journal of molecular biology,
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
November 1979,
FEBS letters,
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
December 1979,
Journal of biochemistry,
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
January 1978,
Doklady Akademii nauk SSSR,
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
March 1979,
Biochemistry,
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
January 1980,
Doklady Akademii nauk SSSR,
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
December 1980,
Molecular biology reports,
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
April 1988,
Biophysical journal,
A D Mirzabekov, and
V V Shick, and
A V Belyavsky, and
S G Bavykin
May 1989,
Cell,
