-transparent.png){kind=logo}
A cDNA clone corresponding to leukotriene A4 hydrolase was isolated from a human lung lambda gt11 expression library by immunoscreening with a polyclonal antiserum. Several additional clones from human lung and placenta cDNA lambda g11 libraries were obtained by plaque hybridization with the 32P-labeled lung cDNA clone. One of these clones has an insert of 1910 base pairs that contains the complete protein-coding region. From the deduced primary structure, leukotriene A4 hydrolase is a 610 amino and protein with a calculated molecular weight of 69,140. No apparent homologies with microsomal epoxide hydrolases were found. RNA blot analysis indicated substantial amounts of a discrete mRNA of approximately equal to 2250 nucleotides in lung tissue and leukocytes.
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
August 1995,
Gene,
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
January 1989,
Advances in prostaglandin, thromboxane, and leukotriene research,
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
August 2002,
Prostaglandins & other lipid mediators,
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
July 1995,
European journal of biochemistry,
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
October 1995,
Journal of lipid mediators and cell signalling,
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
December 2012,
Chemical biology & drug design,
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
March 1992,
FEBS letters,
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
January 1993,
Journal of lipid mediators,
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
January 1990,
Advances in prostaglandin, thromboxane, and leukotriene research,
C D Funk, and
O Rådmark, and
J Y Fu, and
T Matsumoto, and
H Jörnvall, and
T Shimizu, and
B Samuelsson
October 1995,
Bioorganic & medicinal chemistry,
